Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(ACTA1-Il15)10941Lsq
Name:	transgene insertion 10941, LeBris Smith Quinn
MGI ID:	MGI:4417893
Synonyms:	HSA-natLSP-IL15
Transgene:	Tg(ACTA1-Il15)10941Lsq  Location: unknown
Alliance:	Tg(ACTA1-Il15)10941Lsq page

Strain of Origin:

C57BL/6 x C3H

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(ACTA1-Il15)10941Lsq expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Il15 (MGI:103014)   Mutation details: The HSA-natLSP-IL15 transgene was designed with a modified human skeletal actin (HSA or ACTA1) promoter fragment (bases -2139 to +239), murine long signal peptide (LSP) isoform interleukin-15 (Il15) cDNA, and polyA signal. This transgene was microinjected into C57BL/6 x C3H hybrid oocyte pronuclei. Founder mice were identified and bred with C57BL/6J mice to establish line 10941 (with a stable single transgene insertion point). IL-15 mRNA/protein expression in skeletal muscle is approximately 300-fold/400-fold greater in hemizygous males and approximately 100-fold/400-fold greater in hemizygous females, respectively. (J:145611)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:145611 Quinn LS, et al., Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E191-202
All:	2 reference(s)