Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plekhg5tm1.1Jbar
Name:	pleckstrin homology domain containing, family G (with RhoGef domain) member 5; targeted mutation 1.1, Jay Baraban
MGI ID:	MGI:4414815
Synonyms:	Syx-
Gene:	Plekhg5  Location: Chr4:152156955-152199857 bp, + strand  Genetic Position: Chr4, 82.86 cM
Alliance:	Plekhg5tm1.1Jbar page

Germline Transmission:	Earliest citation of germline transmission: J:155152
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: LoxP sites flank the catalytic domain contained in exons 9-13. Germline cre expression results in excision of the floxed exons 9-13. Western blot analysis indicates the loss of full length protein. However, a truncated protein is present. (J:155152)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plekhg5 Mutation:	98 strains or lines available

Original:	J:155152 Garnaas MK, et al., Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. Circ Res. 2008 Sep 26;103(7):710-6
All:	3 reference(s)