Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Tg(FXN)YG22Pook
Name:	transgene insertion YG22, Mark A Pook
MGI ID:	MGI:4412181
Synonyms:	YG22
Transgene:	Tg(FXN)YG22Pook  Location: unknown
Alliance:	Tg(FXN)YG22Pook page

Strain of Origin:

CBA x C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(FXN)YG22Pook expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human FXN (2395) Fxn  (MGI:1096879)   Mutation details: The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG22 was generated, showing a reduced transmission rate of 21%, indicating germ-line mosaicism of the transgene, compared to 52% transmission to offspring for founder line YG8. One copy of the FXN gene was detected, and contains a single 190 GAA repeat sequence. (J:91581)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:91581 Al-Mahdawi S, et al., GAA repeat instability in Friedreich ataxia YAC transgenic mice. Genomics. 2004 Aug;84(2):301-10
All:	5 reference(s)