Tg(SNCA)1Nbm
Transgene Detail
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| Symbol: |
Tg(SNCA)1Nbm |
| Name: |
transgene insertion 1, Robert L Nussbaum |
| MGI ID: |
MGI:4412055 |
| Synonyms: |
hSNCAWT, PAC-Tg(SNCAWT) |
| Transgene: |
Tg(SNCA)1Nbm Location: unknown
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| Alliance: |
Tg(SNCA)1Nbm page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(SNCA)1Nbm expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SNCA (6622) |
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Mutation details: To generate the PAC-Tg(SNCAWT) transgene, the 146 kb RPCI-1 human male P1 artificial chromosome (PAC) clone 27M07, containing the entire human SNCA (synuclein, alpha (non A4 component of amyloid precursor)) gene and 34 kb of its upstream region, was used. This transgene was microinjected into the pronuclei of fertilized FVB/N ova. The only transgenic founder shown to contain the complete SNCA gene was bred to FVB/N wildtype mice.
(J:86222, J:154970)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:86222 Gispert S, et al., Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci. 2003 Oct;24(2):419-29 |
| All: |
10 reference(s) |
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Analysis Tools
