Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(SNCA)1Nbm
Name:	transgene insertion 1, Robert L Nussbaum
MGI ID:	MGI:4412055
Synonyms:	hSNCAWT, PAC-Tg(SNCAWT)
Transgene:	Tg(SNCA)1Nbm  Location: unknown
Alliance:	Tg(SNCA)1Nbm page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(SNCA)1Nbm expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SNCA (6622) Snca  (MGI:1277151)   Mutation details: To generate the PAC-Tg(SNCAWT) transgene, the 146 kb RPCI-1 human male P1 artificial chromosome (PAC) clone 27M07, containing the entire human SNCA (synuclein, alpha (non A4 component of amyloid precursor)) gene and 34 kb of its upstream region, was used. This transgene was microinjected into the pronuclei of fertilized FVB/N ova. The only transgenic founder shown to contain the complete SNCA gene was bred to FVB/N wildtype mice. (J:86222, J:154970)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:86222 Gispert S, et al., Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci. 2003 Oct;24(2):419-29
All:	7 reference(s)