Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Id2tm1.1(cre/ERT2)Blh
Name:	inhibitor of DNA binding 2; targeted mutation 1.1, Brigid L Hogan
MGI ID:	MGI:4398923
Synonyms:	Id2-CreERT2, Id2tm1(CRE/ESR1)Blh
Gene:	Id2  Location: Chr12:25143798-25146091 bp, - strand  Genetic Position: Chr12, 8.57 cM, cytoband B
Alliance:	Id2tm1.1(cre/ERT2)Blh page

Germline Transmission:	Earliest citation of germline transmission: J:154450
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Id2tm1.1(cre/ERT2)Blh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Id2 (MGI:96397)   Mutation details: The targeting vector contained an cre/ERT2 cassette inserted at the translation initiation codon of the Id2 locus, replacing most of exon 1, except for the final 25 nucleotides. The cre cassette was followed by a frt-PGK-neo-frt cassette, which was removed by flp-mediated excision after germline transmission. (J:154450)

Activity:	Tissue activity of this recombinase allele
Driver:	Id2 (mouse) Summary of all recombinase alleles driven by Id2. Comparative matrix view of recombinase activities Alliance mouse Id2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Id2 Mutation:	19 strains or lines available

Original:	J:154450 Rawlins EL, et al., The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. Development. 2009 Nov;136(22):3741-5
All:	27 reference(s)