Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Kcnh5tm1(cre/PGR*)Mim
Name:	potassium voltage-gated channel, subfamily H (eag-related), member 5; targeted mutation 1, Masayoshi Mishina
MGI ID:	MGI:4367714
Synonyms:	Eag2-hCrePR, Kcnh5tm1(cre)Mim, Kcnh5tm1(cre/PGR)Mim
Gene:	Kcnh5  Location: Chr12:74943994-75224106 bp, - strand  Genetic Position: Chr12, 32.62 cM
Alliance:	Kcnh5tm1(cre/PGR*)Mim page

Germline Transmission:	Earliest citation of germline transmission: J:104881
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    mifepristone Mutation:    Insertion   Kcnh5tm1(cre/PGR*)Mim expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Kcnh5 (MGI:3584508)   Mutation details: The endogenous gene's promoter drives expression of a DNA sequence encoding a fusion protein in which Cre recombinase is joined to the ligand binding domain (LBD) of the human progesterone receptor lacking the carboxyl terminal 42 amino acids. The chimeric recombinase protein is not constitutively active; its activity is inducible by binding of the synthetic progesterone analog RU486 to the truncated progesterone LBD. (J:104881, J:122587)

Activity:	Tissue activity of this recombinase allele
Driver:	Kcnh5 (mouse) Summary of all recombinase alleles driven by Kcnh5. Alliance mouse Kcnh5 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnh5 Mutation:	60 strains or lines available

Original:	J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013;
All:	2 reference(s)