Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(CAG-dre)1Afst
Name:	transgene insertion 1, A Francis Stewart
MGI ID:	MGI:4367446
Synonyms:	CAG-Dre, CAGGs-Dre
Transgene:	Tg(CAG-dre)1Afst  Location: unknown
Alliance:	Tg(CAG-dre)1Afst page

Germline Transmission:	Earliest citation of germline transmission: J:154134
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(CAG-dre)1Afst expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: A plasmid in which the CAG (CAGGS) promoter drives the bacteriophage D6 site-specific recombinase (dre). This is followed by an IRES-puromycin sequence for selection. The linearized construct was electroporated into R1 ES cells, and single-copy clones were injected into 8-cell embryos. Germline transmission was obtained for one of these clones. (J:154134)

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:154134 Anastassiadis K, et al., Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice. Dis Model Mech. 2009 Sep-Oct;2(9-10):508-15
All:	21 reference(s)