Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Slc6a4-cre/ERT2)EZ13Gsat
Name:	transgene insertion EZ13, GENSAT Project at Rockefeller University
MGI ID:	MGI:4367233
Synonyms:	Founder Line EZ13, Tg(Slc6a4-cre/Esr1)13Gsat
Transgene:	Tg(Slc6a4-cre/ERT2)EZ13Gsat  Location: unknown
Alliance:	Tg(Slc6a4-cre/ERT2)EZ13Gsat page

Strain of Origin:	FVB/N
Project Collection:	GENSAT

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Slc6a4-cre/ERT2)EZ13Gsat expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Slc6a4 (MGI:96285)   Mutation details: This transgene contains the coding sequence for the Cre-ERT2 fusion protein, followed by a polyadenylation signal, inserted into a mouse genomic artificial chromosome (BAC) at the ATG transcription initiation codon of the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 gene so that expression of the tamoxifen-activated recombinase is driven by the regulatory sequences of the mouse gene. ERT2 is a triply mutated (G400V, M543A, L544A) human estrogen receptor ligand-binding domain that renders the fusion protein highly sensitive to activation by 4-hydroxytamoxifen, but unresponsive to the receptor's native ligands. (J:100256, J:145100)

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a4 (mouse) Summary of all recombinase alleles driven by Slc6a4. Alliance mouse Slc6a4 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:100256 The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY), MGI download of GENSAT transgene data. Database Download. 2005;
All:	7 reference(s)