Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nanogtm1Jae
Name:	Nanog homeobox; targeted mutation 1, Rudolph Jaenisch
MGI ID:	MGI:4366292
Synonyms:	Nanog-Luciferase reporter, NL
Gene:	Nanog  Location: Chr6:122684448-122691592 bp, + strand  Genetic Position: Chr6, 57.8 cM, cytoband F2
Alliance:	Nanogtm1Jae page

Germline Transmission:	Earliest citation of germline transmission: J:153798
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: Most of exon 2 was replaced with a targeting vector including 1.2 kb of the Nanog promoter as a 5' arm, the firefly luciferase gene, SV40 polyadenylation signal sequence, loxP-flanked PGK-neo cassette, and 1.4 kb of intron 2 as a 3' arm. (J:153798)

Generation of the Nanogtm1Jae allele

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nanog Mutation:	46 strains or lines available

Original:	J:153798 Lyssiotis CA, et al., Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7
All:	1 reference(s)