Tg(IVL-MYC/ErT)1348DGev
Transgene Detail
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| Symbol: |
Tg(IVL-MYC/ErT)1348DGev |
| Name: |
transgene insertion 1348D, Gerard Evan |
| MGI ID: |
MGI:2429390 |
| Synonyms: |
c-mycERTM (line 1348D), Inv-c-MycERTAM, involucrin-c-mycERTM, pIns-c-MycERTAM |
| Transgene: |
Tg(IVL-MYC/ErT)1348DGev Location: unknown
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| Alliance: |
Tg(IVL-MYC/ErT)1348DGev page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(IVL-MYC/ErT)1348DGev expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MYC (4609) |
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Mutation details: A tissue specific transgene encoding an inducible MYC protein was generated by coupling the human involucrin promoter to a fusion cDNA encoding the human MYC protein joined to a modified mouse estrogen receptor (ER) ligand binding domain. The Gly525Arg mutant ER domain ("ERTM") responds to 4-hydroxytamoxifen (4OHT) but is insensitive to the endogenous ligand, 17beta-estradiol; therefore, MYC is active only in the presence of 4OHT. Immunohistochemical analysis with antibodies vs. either MYC or ER detected expression of the fusion protein in suprabasal keratinocytes within the intrafollicular epidermis and in the inner root sheath of hair follicles. Line 1348D was estimated by Southern blot analysis to carry 17 copies of the transgene construct.
(J:55801, J:118587)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:55801 Pelengaris S, et al., Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell. 1999 May;3(5):565-77 |
| All: |
5 reference(s) |
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Analysis Tools
