Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Nkx3-1tm4(cre/ERT2)Mms
Name:	NK3 homeobox 1; targeted mutation 4, Michael M Shen
MGI ID:	MGI:4365630
Synonyms:	Nkx3-1CreERT2
Gene:	Nkx3-1  Location: Chr14:69428141-69432107 bp, + strand  Genetic Position: Chr14, 36.02 cM
Alliance:	Nkx3-1tm4(cre/ERT2)Mms page

Germline Transmission:	Earliest citation of germline transmission: J:153425
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Nkx3-1tm4(cre/ERT2)Mms expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Nkx3-1 (MGI:97352)   Mutation details: A cre/ERT2-polyA sequence was inserted at the translation start site of the Nkx3-1 gene, thus generating a null allele. The targeting vector also contained a self-excising ACE-cre/PolII-neo selection cassette for positive selection and a PGK-tk (thymidine kinase) cassette for negative selection. The vector was transfected into TC-1 ES cells which were used to generate chimeras. Excision of the selection cassette occurred by passage through the male germline. (J:153425)

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx3-1 (mouse) Summary of all recombinase alleles driven by Nkx3-1. Comparative matrix view of recombinase activities Alliance mouse Nkx3-1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Nkx3-1tm4(cre/ERT2)Mms

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 14 strains available      Cell Lines: 0 lines available
Carrying any Nkx3-1 Mutation:	39 strains or lines available

Original:	J:153425 Wang X, et al., A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature. 2009 Sep 24;461(7263):495-500
All:	21 reference(s)