Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ern1tm1Tiw
Name:	endoplasmic reticulum to nucleus signalling 1; targeted mutation 1, Takao Iwawaki
MGI ID:	MGI:4365396
Synonyms:	IRE1alpha-
Gene:	Ern1  Location: Chr11:106285476-106378678 bp, - strand  Genetic Position: Chr11, 69.14 cM, cytoband E1
Alliance:	Ern1tm1Tiw page

Germline Transmission:	Earliest citation of germline transmission: J:153222
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette replaced exons 11 - 17 via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygous MEFs. (J:153222)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ern1 Mutation:	57 strains or lines available

Original:	J:153222 Iwawaki T, et al., Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
All:	5 reference(s)