Tg(CAG-cat,-Tbx5)1Nemr
Transgene Detail
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| Symbol: |
Tg(CAG-cat,-Tbx5)1Nemr |
| Name: |
transgene insertion 1, Mona Nemer |
| MGI ID: |
MGI:4361178 |
| Synonyms: |
CAG-CAT-Tbx5 |
| Transgene: |
Tg(CAG-cat,-Tbx5)1Nemr Location: unknown
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| Alliance: |
Tg(CAG-cat,-Tbx5)1Nemr page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CAG-cat,-Tbx5)1Nemr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Tbx5 (MGI:102541) |
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Mutation details: This transgene employs the "CAG promoter," which consists of the cytomegalovirus immediate early (CMV-EI) enhancer followed by a 1.3-kb DNA segment including the promoter, first exon and first intron of the chicken beta-actin gene, with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene. The promoter is separated from a mouse Tbx5 cDNA sequence for the Tbx5a isoform by a floxed chloramphenicol acetyltransferase (cat) gene with the SV40 small t intron and polyadenylation signal. Cre mediated excision of the chloramphenicol acetyltransferase results in Tbx5a expression.
(J:67365, J:137268)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:137268 Georges R, et al., Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation. Mol Cell Biol. 2008 Jun;28(12):4052-67 |
| All: |
3 reference(s) |
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Analysis Tools
