Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Apctm2Rfo Name: APC, WNT signaling pathway regulator; targeted mutation 2, Riccardo Fodde MGI ID: MGI:4360657 Synonyms: Apc1572T Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM Alliance: Apctm2Rfo page

Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:151494
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: A hygro resistance cassette was inserted at a site corresponding to codon 1572. This mutation is predicted to result in a truncated protein. (J:151494)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Apctm2Rfo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:151494 Gaspar C, et al., A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet. 2009 Jul;5(7):e1000547
All:	7 reference(s)