Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ankrd17tm1.1Yty
Name:	ankyrin repeat domain 17; targeted mutation 1.1, Yu-Ting Yan
MGI ID:	MGI:4360512
Synonyms:	Ankrd17delta, Ankrd17deltaE8
Gene:	Ankrd17  Location: Chr5:90375025-90514436 bp, - strand  Genetic Position: Chr5, 44.32 cM, cytoband E2
Alliance:	Ankrd17tm1.1Yty page

Germline Transmission:	Earliest citation of germline transmission: J:152840
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A floxed neo cassette was inserted upstream of exon 8 and an additional loxP site was inserted downstream of exon 8 via homologous recombination. Cre mediated recombination then removed the neo cassette and exon 8. Removal of exon 8 results in a frame shift creating a premature stop codon at nucleotide 45 in exon 9. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:152840)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ankrd17 Mutation:	156 strains or lines available

Original:	J:152840 Hou SC, et al., Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. FEBS Lett. 2009 Sep 3;583(17):2765-71
All:	1 reference(s)