About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:36890 Saga Y, et al., Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:4359755
Gene symbol: Tnc
Gene name: tenascin C
Reporter: lacZ
Direct Detection
Assay notes: The specimens were fixed in 2% paraformaldehyde-0.2% glutaraldehyde.
Results
Specimen 2A: embryonic day 10.0; Tnctm1Sia/Tnc+ (more )
Note: This is a lateral view.
Structure Level Pattern Image Note
TS16: embryo Present 2A Previous studies have shown that expression in the pericardium precedes later expression in the somites and cartilage.

Specimen 2B: embryonic day 11.0; Tnctm1Sia/Tnc+ (more )
Note: This is a lateral view.
Structure Level Pattern Image Note
TS18: embryo Present 2B Previous studies have shown that expression in the pericardium precedes later expression in the somites and cartilage.

Specimen 2C: embryonic day 12.0; Tnctm1Sia/Tnc+ (more )
Note: This is a lateral view.
Structure Level Pattern Image Note
TS20: embryo Present 2C Previous studies have shown that expression in the pericardium precedes later expression in the somites and cartilage.

Specimen 2E: postnatal day 2; Tnctm1Sia/Tnc+ (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS27: lung alveolus Present Regionally restricted 2E Expression is present in relatively large cells located on the alveolar walls adjacent to type-I alveolar cells and at the apex of protrusion of the alveolar septa.

Specimen 2G: embryonic day 18.0; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS26: cerebellum Present Regionally restricted 2G Expression is present in the Bergmann glial cells in the developing Purkinje cell layer.

Specimen 4 lung +/-: postnatal day 12; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS28: lung Present 4A lung +/- LacZ

Specimen 4 lung -/-: postnatal day 12; Tnctm1Sia/Tnctm1Sia (more )
Structure Level Pattern Image Note
TS28: lung Present 4A lung -/- LacZ As expected, expression levels are stronger in homozygotes compared to heterozygotes.

Specimen 4 thymus +/-: postnatal day 12; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS28: thymus Present 4A thymus +/- LacZ

Specimen 4 thymus -/-: postnatal day 12; Tnctm1Sia/Tnctm1Sia (more )
Structure Level Pattern Image Note
TS28: thymus Present 4A thymus -/- LacZ As expected, expression levels are stronger in homozygotes compared to heterozygotes.

Specimen 4 cerebellum +/-: postnatal day 12; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 4A cerebellum +/- LacZ

Specimen 4 cerebellum -/-: postnatal day 12; Tnctm1Sia/Tnctm1Sia (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 4A cerebellum -/- LacZ As expected, expression levels are stronger in homozygotes compared to heterozygotes.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory