Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Klk4tm1.1Jpsi Name: kallikrein related-peptidase 4 (prostase, enamel matrix, prostate); targeted mutation 1.1, James P Simmer MGI ID: MGI:4355346 Synonyms: Klk4lacZ Gene: Klk4  Location: Chr7:43530584-43535228 bp, + strand  Genetic Position: Chr7, 28.35 cM Alliance: Klk4tm1.1Jpsi page

Abnormal dental enamel of Klk4tm1.1Jpsi/Klk4tm1.1Jpsi incisors Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:151626
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The genomic sequence spanning the initiation codon in exon 2 through exon 6 was replaced with an NLS-lacZ and floxed neo cassette. The neo cassette was subsequently removed by germ line, cre mediated recombination. This allele lacks the entire coding region. (J:151626)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Klk4 Mutation:	21 strains or lines available

Original:	J:151626 Simmer JP, et al., Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. J Biol Chem. 2009 Jul 10;284(28):19110-21
All:	8 reference(s)