Dlx5tm1(cre/ERT2)Zjh
Targeted Allele Detail
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Symbol: |
Dlx5tm1(cre/ERT2)Zjh |
Name: |
distal-less homeobox 5; targeted mutation 1, Z Josh Huang |
MGI ID: |
MGI:4355155 |
Synonyms: |
Dlx5-CreER, Dlx5-CreERT2 |
Gene: |
Dlx5 Location: Chr6:6877801-6882068 bp, - strand Genetic Position: Chr6, 2.83 cM
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Alliance: |
Dlx5tm1(cre/ERT2)Zjh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:151755
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Project Collection: |
Neuroscience Blueprint cre
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Allele Type: |
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Targeted (Inducible, Null/knockout, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Dlx5tm1(cre/ERT2)Zjh expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Dlx5 (distal-less homeobox 5) gene. This construct was electroporated into C57BL/6 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with white C57BL/6 mice to originate the colony. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background (N10)) to remove the neo selection cassette.
(J:151755)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Dlx5
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009; |
All: |
9 reference(s) |
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