Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ssttm1(cre/ERT2)Zjh
Name:	somatostatin; targeted mutation 1, Z Josh Huang
MGI ID:	MGI:4355153
Synonyms:	SOM-CreER, SOM-CreERT2, Sst-CreER, Sst-CreERT2
Gene:	Sst  Location: Chr16:23708323-23709708 bp, - strand  Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
Alliance:	Ssttm1(cre/ERT2)Zjh page

Germline Transmission:	Earliest citation of germline transmission: J:151755
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6
Project Collection:	Neuroscience Blueprint cre

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Ssttm1(cre/ERT2)Zjh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sst (MGI:98326)   Mutation details: A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Sst (somatostatin) gene. This construct was electroporated into C57BL/6 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with white C57BL/6 mice to originate the colony. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background (N10)) to remove the neo selection cassette. These Sst-CreERT2 mice were subsequently bred together (selectively removing the FLPe transgene). (J:151755)

Activity:	Tissue activity of this recombinase allele
Driver:	Sst (mouse) Summary of all recombinase alleles driven by Sst. Comparative matrix view of recombinase activities Alliance mouse Sst gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sst Mutation:	35 strains or lines available

Original:	J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:	15 reference(s)