Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Hoxb7-cre)1Jpa
Name:	transgene insertion 1, Juha Partanen
MGI ID:	MGI:4354304
Synonyms:	MHB-cre
Transgene:	Tg(Hoxb7-cre)1Jpa  Location: unknown
Alliance:	Tg(Hoxb7-cre)1Jpa page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Hoxb7-cre)1Jpa expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Hoxb7   Mutation details: The Hoxb7 promoter fragment from -1316 to +8 bp from the translation initiation codon into the CORE expression vector containing a cDNA encoding the reverse tetracycline-responsive transactivator (rtTA) sequence upstream of cDNA encoding cre recombinase controlled by a CMV minimal promoter linked to the tet operator (tetO) sequence. The construct was injected into the male pronucleus of fertilized oocytes. Eight founder animals were obtained and cre activity was analyzed by crossing the animals to R26R reporter mice. In this line, cre expression was restricted to cells at the midbrain-hindbrain boundary. The pattern of cre activity was not affected by doxycycline, indicating cre expression is not controlled the rtTA protein expressed from the Hoxb7 promoter. (J:135242)

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxb7 (species not specified) Summary of all recombinase alleles driven by Hoxb7. Comparative matrix view of recombinase activities

In Mice Carrying this Mutation:

9 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:135242 Kala K, et al., Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain. Genesis. 2008 Jan;46(1):29-36
All:	1 reference(s)