Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	ClockGt(P007F12)Wrst
Name:	clock circadian regulator; gene trap P007F12, German Gene Trap Consortium
MGI ID:	MGI:4340066
Gene:	Clock  Location: Chr5:76357715-76452639 bp, - strand  Genetic Position: Chr5, 40.63 cM
Alliance:	ClockGt(P007F12)Wrst page

Mutant Cell Line:	P007F12
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	IDG3.2 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S6/SvEvTac)F1

Allele Type:    Gene trapped (Null/knockout) Mutation:    Insertion of gene trap vector     Vector: FlipROSAbetageo   Mutation details: A "FlipROSAgeo" genetrap inserted in intron 2-3 of the Clock (circadian locomotor output cycles kaput) locus disrupts gene expression to create a null allele. Loss of expression (confirmed in hypothalamus, cerebellum, liver and kidney) does not severely attenuate the expression levels and oscillations of other core circadian transcripts. Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select P007F12 CL303090 (MGI Seq Detail) 5' RACE Chr5:76451270-76452617 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 44 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clock Mutation:	101 strains or lines available

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	3 reference(s)