Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mrgprdtm1.1(cre)And
Name:	MAS-related GPR, member D; targeted mutation 1.1, David Anderson
MGI ID:	MGI:3852395
Synonyms:	Mrgprd-Cre-
Gene:	Mrgprd  Location: Chr7:144868572-144877796 bp, + strand  Genetic Position: Chr7, 89.06 cM
Alliance:	Mrgprdtm1.1(cre)And page

Germline Transmission:	Earliest citation of germline transmission: J:150802
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Mrgprdtm1.1(cre)And expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Mrgprd (MGI:3033142)   Mutation details: Most of the open reading frame was replaced with a cassette containing EGFP, cre, and frt flanked neo that was inserted out of frame with the initiation site. The inserted cassette replaced amino acids 20 through 315 of the total 321 amino acids of the endogenous protein. Germ line, flp mediated recombination removes the neo cassette. (J:150802)

Activity:	Tissue activity of this recombinase allele
Driver:	Mrgprd (mouse) Summary of all recombinase alleles driven by Mrgprd. Alliance mouse Mrgprd gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mrgprd Mutation:	24 strains or lines available

Original:	J:150802 Rau KK, et al., Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J Neurosci. 2009 Jul 1;29(26):8612-9
All:	9 reference(s)