Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pde1ctm1.1Hazh
Name:	phosphodiesterase 1C; targeted mutation 1.1, Haiqing Zhao
MGI ID:	MGI:3851438
Gene:	Pde1c  Location: Chr6:56046789-56629472 bp, - strand  Genetic Position: Chr6, 27.65 cM
Alliance:	Pde1ctm1.1Hazh page

Germline Transmission:	Earliest citation of germline transmission: J:150514
Parent Cell Line:	MC1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The targeting vector was designed to replace exons 5-8, which encodes the N-terminal portion of the predicted catalytic domain, with a floxed neomycin cassette and to insert a stop codon in the remainder of exon 5. Founder mice were crossed with cre transgenic mice to remove the neomycin cassette. No protein product was detected in the cilia layer of homozygote olfactory epithelium as determined by immunohistochemistry. (J:150514)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde1c Mutation:	36 strains or lines available

Original:	J:150514 Cygnar KD, et al., Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci. 2009 Apr;12(4):454-62
All:	5 reference(s)