Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cul4atm1.2Pz
Name:	cullin 4A; targeted mutation 1.2, Pengbo Zhou
MGI ID:	MGI:3851025
Synonyms:	Cul4a-
Gene:	Cul4a  Location: Chr8:13155623-13197940 bp, + strand  Genetic Position: Chr8, 5.73 cM
Alliance:	Cul4atm1.2Pz page

Germline Transmission:	Earliest citation of germline transmission: J:150427
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Mice containing the allele Cul4atm1.1Pz were crossed with Ella-cre transgenic mice to excise the floxed exons 17-19 from germline cells. A C-terminal truncated protein was detected at 8% of endogenous levels in homozygote embryonic fibroblasts by immunoblot analysis. This protein product failed to interact with RBX1 for recruitment of the E2 ubiquitin-conjugating enzyme and thus was considered functionally null. (J:150427)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cul4a Mutation:	30 strains or lines available

Original:	J:150427 Liu L, et al., CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell. 2009 May 14;34(4):451-60
All:	2 reference(s)