Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mtortm1.2Koz
Name:	mechanistic target of rapamycin kinase; targeted mutation 1.2, Sara C Kozma
MGI ID:	MGI:3850506
Synonyms:	Frap1fl, mTORfl, mTORflox
Gene:	Mtor  Location: Chr4:148533068-148642140 bp, + strand  Genetic Position: Chr4, 78.76 cM, cytoband E1
Alliance:	Mtortm1.2Koz page

Germline Transmission:	Earliest citation of germline transmission: J:150108
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 5. Transient cre expression in ES cells removed the neo cassette creating this allele. (J:150108, J:162918)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	110 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mtor Mutation:	115 strains or lines available

Original:	J:150108 Delgoffe GM, et al., The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009 Jun 19;30(6):832-44
All:	78 reference(s)