Tg(tetO-Erbb2*)8-4Jek
Transgene Detail
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| Symbol: |
Tg(tetO-Erbb2*)8-4Jek |
| Name: |
transgene insertion 8-4, Jeffrey E Kudlow |
| MGI ID: |
MGI:3850387 |
| Synonyms: |
TetRE-ErbB2, TRE-ErbB2, TRE-Neu |
| Transgene: |
Tg(tetO-Erbb2*)8-4Jek Location: unknown
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| Alliance: |
Tg(tetO-Erbb2*)8-4Jek page
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| Strain of Origin: |
(C57BL/6 x SJL)
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| Transgene Type: |
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Transgenic (Constitutively active, Inducible, Inserted expressed sequence) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Tg(tetO-Erbb2*)8-4Jek expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| rat |
Erbb2 (24337) |
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Mutation details: The TetRE-ErbB2 (pTRE-Neu-SV40) transgene was designed with the tetracycline operator (tetO; also called tetracycline-responsive element (TRE, TetRE) or tet-operator) and cytomegalovirus minimal promoter, a 4.8 kb cDNA sequence from the activated form of rat c-neu/erbB2 (ErbB2; with Val to Glu mutation within the transmembrane domain at amino acid 664), and an SV40 intron/polyA sequence. This 6.8 kb transgene was microinjected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 8-4 were bred with wildtype sibling mice to establish the colony.
(J:55970)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:55970 Xie W, et al., Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice. Oncogene. 1999 Jun 17;18(24):3593-607 |
| All: |
9 reference(s) |
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Analysis Tools
