Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-Egfr*)2-9Jek
Name:	transgene insertion 2-9, Jeffrey E Kudlow
MGI ID:	MGI:3850383
Synonyms:	TetRE-EGFR-tr, TRE-EGFR-tr
Transgene:	Tg(tetO-Egfr*)2-9Jek  Location: unknown
Alliance:	Tg(tetO-Egfr*)2-9Jek page

Strain of Origin:

(C57BL/6 x SJL)

Transgene Type:    Transgenic (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-Egfr*)2-9Jek expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Egfr (MGI:95294)   Mutation details: The TetRE-EGFRtr-SV40 transgene was designed with the tetracycline operator (tetO; also called tetracycline-responsive element (TRE, TetRE) or tet-operator) and cytomegalovirus minimal promoter, a 2.3 kb C-terminal truncated mouse epidermal growth factor receptor cDNA sequence (EGFR-tr; encoding amino acid 1-690 followed by a TGA stop codon), and an SV40 intron/polyA sequence. This 4.5 kb transgene was microinjected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder lines 2-9 were bred with C57BL/6;SJL wildtype mice to establish the colony. (J:68692)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:68692 Roh M, et al., Stage-sensitive blockade of pituitary somatomammotrope development by targeted expression of a dominant negative epidermal growth factor receptor in transgenic mice. Mol Endocrinol. 2001 Apr;15(4):600-13
All:	4 reference(s)