Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Tgfb1tm2.1Doe Name: transforming growth factor, beta 1; targeted mutation 2.1, Thomas Doetschman MGI ID: MGI:3849964 Synonyms: Tgfb1flox ex6 Gene: Tgfb1  Location: Chr7:25386427-25404502 bp, + strand  Genetic Position: Chr7, 13.98 cM Alliance: Tgfb1tm2.1Doe page

Lung and salivary gland inflammation in Tgfb1tm2.1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:150024
Parent Cell Line:	KG-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neomycin cassette was placed upstream of exon 6 with an additional loxP site placed downstream of exon 6. The neomycin cassette was subsequently removed by transient expression of cre recombinase leaving exon 6 floxed. Germline transmission of the allele was confirmed by genomic PCR. (J:150024)

Generation of the Tgfb1tm2.1Doe allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfb1 Mutation:	34 strains or lines available

Original:	J:150024 Azhar M, et al., Generation of mice with a conditional allele for transforming growth factor beta 1 gene. Genesis. 2009 Jun;47(6):423-31
All:	30 reference(s)