Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Camk2atm1.1Oyam
Name:	calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1.1, Yoko Yamagata
MGI ID:	MGI:3849851
Synonyms:	CaMKIIalpha(K42R)
Gene:	Camk2a  Location: Chr18:61058704-61121224 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Camk2atm1.1Oyam page

Germline Transmission:	Earliest citation of germline transmission: J:150046
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Single point mutation   Mutation details: Exon 2 was replaced with one in which an A to G transition results in an amino acid substitution of arginine for lysine at position 42 (K42R). This mutation abolishes the kinase activity of the protein product, as determined by enzymatic assays. A floxed neo cassette inserted downstream of exon 2 was removed by transient cre expression in ES cells. (J:150046)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Camk2a Mutation:	136 strains or lines available

Original:	J:150046 Yamagata Y, et al., Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning. J Neurosci. 2009 Jun 10;29(23):7607-18
All:	5 reference(s)