Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(HLA-A24/H2-D/B2M)3Dvs
Name:	transgene insertion 3, David Serreze
MGI ID:	MGI:3848818
Synonyms:	A24/HHD
Transgene:	Tg(HLA-A24/H2-D/B2M)3Dvs  Location: unknown
Alliance:	Tg(HLA-A24/H2-D/B2M)3Dvs page

Strain of Origin:

NOD/ShiLtDvs

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(HLA-A24/H2-D/B2M)3Dvs expresses 2 genes Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human B2M (567) B2m  (MGI:88127) mouse H2-D (MGI:1933561)   Mutation details: This transgene encodes human B2-microglubulin (B2M) covalently linked to the alpha1 and alpha2 peptide binding domains of the human HLA-A24 MHC class I gene, as well as the alpha3, cytoplasmic and transmembrane domains of the murine H2-Db class I variant. Human HLA-A2.1 and HLA-A24 have both been associated with T1D in humans. (J:149657) Inheritance:    Dominant

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:149657 Serreze DV, Generation of humanized HLA-A24 transgenic NOD mice. MGI Direct Data Submission. 2009;
All:	2 reference(s)