Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(SERPINA1*E342K)#Slcw
Name:	transgene insertion, Savio L C Woo
MGI ID:	MGI:3847801
Synonyms:	ATZ, PiZ, Tg(SERPINA1*E342K)Z1.01Slcw, Z1.01
Transgene:	Tg(SERPINA1*E342K)#Slcw  Location: unknown
Alliance:	Tg(SERPINA1*E342K)#Slcw page

Strain of Origin:

(ICR x C57BL/6)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(SERPINA1*E342K)#Slcw expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SERPINA1 (5265) Serpina1a  (MGI:891971) Serpina1b  (MGI:891970) Serpina1c  (MGI:891969) Serpina1d  (MGI:891968) Serpina1e  (MGI:891967) There is a single gene in human and 5 homologs in mouse.   Mutation details: The transgene construct contains the entire human alpha1-antitrypsin (AAT or SERPINA1) gene encoding the Z variant allele which has a Glu->Lys substitution at position 342, plus 2.0 and 2.3 kb of 5' and 3' genomic sequences, respectively. (J:149132, J:149133)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:149132 Carlson JA, et al., Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice. J Clin Invest. 1989 Apr;83(4):1183-90
All:	14 reference(s)