Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Slc6a3-PARK2*Q311X)AXwy
Name:	transgene insertion A, X William Yang
MGI ID:	MGI:3845880
Synonyms:	Parkin-Q311X(A), Parkin-Q311X line A, TgA
Transgene:	Tg(Slc6a3-PARK2*Q311X)AXwy  Location: unknown
Alliance:	Tg(Slc6a3-PARK2*Q311X)AXwy page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Slc6a3-PARK2*Q311X)AXwy expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human PRKN (5071) Prkn  (MGI:1355296)   Mutation details: A 200 kb mouse bacterial artificial chromosome (BAC) RP23-408F13 contains the entire 50 kb Slc6a3 gene (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; also called dopamine transporter (DAT)) and other genes in the approximately 100 kb of 5' and 40 kbp of 3' flanking sequences. This BAC was modified by inserting a parkin-Q311X cDNA sequence (FLAG-tagged mutant human parkin gene (PARK2; Parkinson disease (autosomal recessive, juvenile) 2, parkin) carrying the Q311X truncation associated with Turkish early-onset Parkinson's disease and followed by a polyA signal) into Slc6a3 exon 2 upstream of the translation initiation codon. This modified Slc6a3-parkin(Q311X) BAC was microinjected into fertilized FVB/NJ zygotes. Line A (found to harbor two tandem integrates of the transgene) was subsequently established. (J:146833)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:146833 Lu XH, et al., Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J Neurosci. 2009 Feb 18;29(7):1962-76
All:	2 reference(s)