Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Thy1-Nlgn2)6Hnes
Name:	transgene insertion 6, Rochelle Hines
MGI ID:	MGI:3844455
Synonyms:	TgNL2.6
Transgene:	Tg(Thy1-Nlgn2)6Hnes  Location: unknown
Alliance:	Tg(Thy1-Nlgn2)6Hnes page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Thy1-Nlgn2)6Hnes expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Nlgn2 (MGI:2681835)   Mutation details: The TgNL2 transgene was designed with a modified regulatory region of the "murine thy1.2 gene" (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns) upstream of a hemagglutinin-tagged rat neuroligin 2 (Nlgn2 or NL2) cDNA. Transgenic founders were bred with C57BL/6 and mice from founder line 6 (TgNL2.6) were found to have an approximately 1.6-fold increase in NL2 expression and moderate phenotype severity, (J:137376)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:137376 Hines RM, et al., Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci. 2008 Jun 11;28(24):6055-67
All:	1 reference(s)