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Phenotypes Associated with This Genotype
Genotype
MGI:3844327
Allelic
Composition		 Il4ratm1Sz/Il4ratm1Sz
Genetic
Background		 BALB/c-Il4ratm1Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation (3 available); any Il4ra mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgG2a level ( J:110429 )
• mice make increased levels of IgG2 in response to N. brasiliensis infection
increased susceptibility to parasitic infection ( J:110429 )
• 15 days after inoculation with N. brasiliensis, intestines contain large numbers of adult worms while controls have expelled the worms by this time point

hematopoietic system
increased IgG2a level ( J:110429 )
• mice make increased levels of IgG2 in response to N. brasiliensis infection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory