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Gene Expression Data
Assay Details
Assay
Reference: J:75947 van den Akker E, et al., Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development. 2002 May;129(9):2181-93
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3840796
Gene symbol: Hoxb8
Gene name: homeobox B8
Reporter: lacZ
Direct Detection
Results
Specimen 5A: embryonic day 11.5-12.0; Hoxb8tm1.1Jdes/Hoxb8+ (more )
Structure Level Pattern Image Note
TS19: vertebral pre-cartilage condensation Present Regionally restricted 5A The anterior expression boundary was detected in prevertebra 7.
Specimen 5B: embryonic day 11.5-12.0; Cdx2tm1Fbe/Cdx2+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Structure Level Pattern Image Note
TS19: vertebral pre-cartilage condensation Present Regionally restricted 5B The anterior expression boundary was shifted in the mutant. Expression was either very weak or lost in prevertebra 7 and was reduced in prevertebra 8.
Specimen 5C: embryonic day 11.5-12.0; Cdx1tm1Pgr/Cdx1+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Structure Level Pattern Image Note
TS19: vertebral pre-cartilage condensation Present Regionally restricted 5C As in wild type, the anterior expression boundary was detected in prevertebra 7.
Specimen 5D: embryonic day 11.5-12.0; Cdx1tm1Pgr/Cdx1tm1Pgr, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Structure Level Pattern Image Note
TS19: vertebral pre-cartilage condensation Present Regionally restricted 5D Expression was weak in prevertebra 7.
Specimen 5E: embryonic day 11.5-12.0; Cdx1tm1Pgr/Cdx1+, Cdx2tm1Fbe/Cdx2+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Structure Level Pattern Image Note
TS19: vertebral pre-cartilage condensation Present Regionally restricted 5E The anterior expression boundary was shifted in the mutant. The most anterior expression was seen in prevertebra 8.
Specimen 5F: embryonic day 11.5-12.0; Cdx1tm1Pgr/Cdx1tm1Pgr, Cdx2tm1Fbe/Cdx2+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Structure Level Pattern Image Note
TS19: vertebral pre-cartilage condensation Present Regionally restricted 5F The anterior expression boundary was shifted in the mutant. Expression was either very weak or lost in prevertebra 8. The most rostral strong expression was detected in prevertebra 9.
Specimen 7A Cdx1+/-: embryonic day 9.0; Cdx1tm1Pgr/Cdx1+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Note: 17 somites.
Structure Level Pattern Image Note
TS14: future spinal cord Present Regionally restricted 7A Cdx1+/- The neurectodermal anterior expression boundary was located at a level halfway up the fifth somite.
Specimen 7A Cdx1-/-;Cdx2+/-: embryonic day 9.0; Cdx1tm1Pgr/Cdx1tm1Pgr, Cdx2tm1Fbe/Cdx2+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Note: 17 somites.
Structure Level Pattern Image Note
TS14: future spinal cord Present Regionally restricted 7A Cdx1-/-;Cdx2+/- In the double mutant, the neurectodermal anterior expression boundary was shifted posteriorly by the extent of one somite level. The boundary was located at a level halfway up the sixth somite.
Specimen 7B Cdx1+/-: embryonic day 9.0; Cdx1tm1Pgr/Cdx1+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Note: 17 somites.
Structure Level Pattern Image Note
TS14: somite 10 Present 7B Cdx1+/-
TS14: somite 11 Present 7B Cdx1+/-
TS14: trunk somite Present Regionally restricted 7B Cdx1+/- The anterior expression boundary in paraxial mesoderm was detected at the level of somite 10/11.
Specimen 7B Cdx1-/-;Cdx2+/-: embryonic day 9.0; Cdx1tm1Pgr/Cdx1tm1Pgr, Cdx2tm1Fbe/Cdx2+, Hoxb8tm1.1Jdes/Hoxb8+ (more )
Note: 17 somites.
Structure Level Pattern Image Note
TS14: somite 12 Present 7B Cdx1-/-;Cdx2+/-
TS14: trunk somite Present Regionally restricted 7B Cdx1-/-;Cdx2+/- Expression level was reduced in the double mutant. The anterior expression boundary in paraxial mesoderm was located more posteriorly at the level of somite 12.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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