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Gene Expression Data
Assay Details
Assay
Reference: J:24337 Akazawa C, et al., A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J Biol Chem. 1995 Apr 14;270(15):8730-8
Assay type: RNA in situ
MGI Accession ID: MGI:3840773
Gene symbol: Atoh1
Gene name: atonal bHLH transcription factor 1
Probe: MATH-1 probe
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen not shown: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: embryo Absent

Specimen 3a: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trigeminal preganglion Present 3a

Specimen 3b: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: central nervous system Present 3b Expression in the dorsal wall of the neural tube.

Specimen 3c: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: trigeminal ganglion Weak 3c

Specimen 3d: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: central nervous system Strong Regionally restricted 3d High levels of expression throughout the dorsal part of the neural tube.

Specimen 3e: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: central nervous system Strong Regionally restricted 3e High levels of expression throughout the dorsal part of the neural tube.

Specimen 4a: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forebrain Absent 4a Authors state that expression was undetectable in the forebrain.
TS20: midbrain Weak Regionally restricted 4a Weak expression in the dorsal part of the midbrain.
TS20: hindbrain Strong Regionally restricted 4a Prominent expression in the alar plate of the hindbrain, located dorsolateral to the basal plate.
TS20: spinal cord Strong Regionally restricted 4a High levels of expression in the spinal cord restricted to the dorsal ventricular zone and alar plates, with highest levels in the most dorsal region.

Specimen 4b: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindbrain alar plate Strong 4b Prominent expression in the alar plate of the hindbrain,
TS20: hindbrain lateral wall Strong Regionally restricted 4b High expression in the ventrally and dorsally migrating cells of the alar plate of the hindbrain.
TS20: metencephalon Present Regionally restricted 4b Expression in ventrally migrating cells corresponding the the bulbopontine extension, which later forms the pontine nuclei rostrally and the olivary nuclear complex caudally.
TS20: cerebellum primordium Present Regionally restricted 4b Expression in dorsally migrating cells forming the external granule layer of the cerebellar cortex.
TS20: spinal cord Present Regionally restricted 4b High levels of expression in the spinal cord restricted to the dorsal ventricular zone and alar plates, with highest levels in the most dorsal region.

Specimen 4c: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord Strong Regionally restricted 4c High levels of expression in the spinal cord restricted to the dorsal ventricular zone and alar plates, with highest levels in the most dorsal region.

Specimen 5a: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: forebrain Absent 5a
TS21: midbrain Absent 5a
TS21: hindbrain Present Regionally restricted 5a Expression in the dorsal part of the hindbrain,
TS21: metencephalon Strong Regionally restricted 5a Highest levels in the metencephalon.
TS21: medulla oblongata Present 5a Expression in the myelencephalon.
TS21: spinal cord Present Regionally restricted 5a Expression in the dorsal part of the spinal cord.

Specimen 5b: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: cerebellum Present 5b Expression in the brain restricted to the cerebellum.
TS26: spinal cord Absent 5b
TS26: alimentary system Present 5b Expression in the gastrointestinal tract.

Specimen 6Aa: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present 6Aa Expression in the CNS restricted to the external granular layer of the cerebellum.

Specimen 6Ab: postnatal day 11 (more )
Structure Level Pattern Image Note
TS28: cerebellum internal granule cell layer Present 6Ab Authors report that expression in the external granular layer gradually decreased postnatally.

Specimen 6Ac: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present 6Ac Authors report that expression in the external granular layer gradually decreased postnatally.

Specimen 6Ad: postnatal day 28 (more )
Structure Level Pattern Image Note
TS28: nervous system Absent 6Ad Authors report that there was no detectable expression in the nervous system.

Specimen 6Ba: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present 6Ba
TS27: cerebellum internal granule cell layer Absent 6Ba

Specimen 6Bb: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present 6Bb
TS28: cerebellum internal granule cell layer Absent 6Bb

Specimen 7Ba: postnatal adult (more )
Structure Level Pattern Image Note
TS28: alimentary system epithelium Present 7Ba Expression in epithelial cells of the gastrointestinal tract
TS28: alimentary system Present Regionally restricted 7Ba No expression in neural cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory