Nup155<Gt(RRD107)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3840086)

Nup155^{Gt(RRD107)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Nup155^{Gt(RRD107)Byg}
Name:	nucleoporin 155; gene trap RRD107, BayGenomics
MGI ID:	MGI:3840086
Synonyms:	Nup155^-
Gene:	Nup155 Location: Chr15:8138757-8190731 bp, + strand Genetic Position: Chr15, 3.82 cM, cytoband A2
Alliance:	Nup155^{Gt(RRD107)Byg} page

Mutation
origin

Mutant Cell Line:	RRD107
Germline Transmission:	Earliest citation of germline transmission: J:147210
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap

Mutation details: The gene trap vector containing a beta-geo cassette inserted into intron 5. Insertion results in a truncated protein of only 217 amino acids (of 1391). A 50% reduction in protein expression was confirmed by western blot analysis on extracts from heterozygous mice. (J:147210)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nup155 Mutation:	94 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:147210 Zhang X, et al., Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death. Cell. 2008 Dec 12;135(6):1017-27
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23