Brd2<Gt(RRE050)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3840071)

Brd2^{Gt(RRE050)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Brd2^{Gt(RRE050)Byg}
Name:	bromodomain containing 2; gene trap RRE050, BayGenomics
MGI ID:	MGI:3840071
Synonyms:	brd2 lo
Gene:	Brd2 Location: Chr17:34330993-34341581 bp, - strand Genetic Position: Chr17, 17.98 cM, cytoband D
Alliance:	Brd2^{Gt(RRE050)Byg} page

Mutation
origin

Mutant Cell Line:	RRE050
Germline Transmission:	Earliest citation of germline transmission: J:147040
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap

Mutation details: The gene trap vector was inserted into the intron downstream of the first translation initiation site. In situ hybridization confirmed the absence of RNA expression in homozygous embryos. (J:147040, J:159964)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	29 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Brd2 Mutation:	43 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:147040 Shang E, et al., Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse. Dev Dyn. 2009 Apr;238(4):908-17
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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