Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp53bp2tm1Cdlo
Name:	transformation related protein 53 binding protein 2; targeted mutation 1, Charles D Lopez
MGI ID:	MGI:3839864
Synonyms:	ASPP2-
Gene:	Trp53bp2  Location: Chr1:182236737-182289997 bp, + strand  Genetic Position: Chr1, 84.93 cM
Alliance:	Trp53bp2tm1Cdlo page

Germline Transmission:	Earliest citation of germline transmission: J:146764
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 10 - 17 were replaced with a floxed neo cassette via homologous recombination. Western blot analysis indicates about a 2-fold reduction in protein expression in MEFs, thymus and liver from heterozygous mice. (J:146764)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Trp53bp2tm1Cdlo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53bp2 Mutation:	52 strains or lines available

Original:	J:146764 Kampa KM, et al., Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4390-5
All:	4 reference(s)