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Tg(Gfap-cre)77.6Mvs
Transgene Detail
Summary
Symbol: Tg(Gfap-cre)77.6Mvs
Name: transgene insertion 77.6, Michael V Sofroniew
MGI ID: MGI:3838840
Synonyms: mGFAP-Cre
Transgene: Tg(Gfap-cre)77.6Mvs  Location: unknown  
Alliance: Tg(Gfap-cre)77.6Mvs page
Transgene
origin
Strain of Origin:  (BALB/c x C57BL/6NHsd)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Gfap-cre)77.6Mvs expression driven by 1 gene
 
Mutation detailsThe bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. Cre expression was detected in a small population of cells within the subependymal zone in the adult brain. No Cre expression or activity was detected during embryonic development or in the hippocampus. (J:94543, J:146630)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gfap (mouse)
Summary of all recombinase alleles driven by Gfap.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:146630 Gregorian C, et al., Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11;29(6):1874-86
All:  98 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory