Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Agpat2tm1Garg
Name:	1-acylglycerol-3-phosphate O-acyltransferase 2; targeted mutation 1, Abhimanyu Garg
MGI ID:	MGI:3838346
Gene:	Agpat2  Location: Chr2:26483069-26494429 bp, - strand  Genetic Position: Chr2, 18.96 cM
Alliance:	Agpat2tm1Garg page

Germline Transmission:	Earliest citation of germline transmission: J:146649
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Genomic sequence spanning from upstream of exon 1 through exon 4 was replaced with a neo cassette. RT-PCR confirmed the absence of transcript expression. Enzymatic activity of the targeted protein is reduced to 10% of wild-type. (J:146649)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agpat2 Mutation:	19 strains or lines available

Original:	J:146649 Cortes VA, et al., Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 2009 Feb;9(2):165-76
All:	9 reference(s)