Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aurkatm1.2Tvd
Name:	aurora kinase A; targeted mutation 1.2, Terry Van Dyke
MGI ID:	MGI:3836423
Synonyms:	AurAd2
Gene:	Aurka  Location: Chr2:172198110-172212455 bp, - strand  Genetic Position: Chr2, 94.84 cM
Alliance:	Aurkatm1.2Tvd page

Germline Transmission:	Earliest citation of germline transmission: J:145744
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An frt and loxP flanked neo cassette was inserted into intron 1 and a third loxP site was inserted into intron 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. Deletion of exon 2 removes the ATg start site. Absence of protein expression was confirmed in blastocysts. (J:145744)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

18 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aurka Mutation:	40 strains or lines available

Original:	J:145744 Cowley DO, et al., Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol. 2009 Feb;29(4):1059-71
All:	1 reference(s)