Analysis Tools
nervous system
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• following induction with KCl, spreading depression frequency and propagation speed are increased compared to in wild-type mice but not as much as in homozygotes
• KCl-induced cortical spreading depressions propagate into the striatum unlike in wild-type mice but not as much as in homozygous mice
• mice exhibit 1 or more recurrent spreading depressions following brief topical KCl application and extensive washing unlike in wild-type mice
• however, recovery of cortical evoked potentials after KCl-induced spreading depression is normal
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homeostasis/metabolism
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• topical application of 300 mM KCl induces a single spreading depression that causes impairments in coordination not observed in wild-type mice that are not as severe as in homozygous mice
• KCl-induced cortical spreading depressions propagate into the striatum unlike in wild-type mice but not as much as in homozygous mice
• mice exhibit 1 or more recurrent spreading depressions following brief topical KCl application and extensive washing unlike in wild-type mice
• however, recovery of cortical evoked potentials after KCl-induced spreading depression is normal
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behavior/neurological
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• topical application of 300 mM KCl induces a single spreading depression that causes impairments in coordination not observed in wild-type mice that are not as severe as in homozygous mice
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