Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli
Transgene Detail
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| Symbol: |
Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli |
| Name: |
transgene insertion 1, Jack A Elias |
| MGI ID: |
MGI:3836054 |
| Synonyms: |
CC10-dnMEK1 Tg |
| Transgene: |
Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli Location: unknown
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| Alliance: |
Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Map2k1 (MGI:1346866) |
Transgene codes for a protein with two serine to valine mutations. |
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Mutation details: A rat CC10
promoter drives lung-specific expression of a Map2k1
sequence in which serines 218 and 222 had been mutated to valines (dnMEK1). A human
growth hormone polyadenylation sequence is added at the 3' end of the construct.
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:105338 Lee PJ, et al., ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006 Jan;116(1):163-73 |
| All: |
2 reference(s) |
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Analysis Tools
