Tg(Scgb1a1-rtTA,tetO-Il11)1Eli
Transgene Detail
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| Symbol: |
Tg(Scgb1a1-rtTA,tetO-Il11)1Eli |
| Name: |
transgene insertion 1, Jack A Elias |
| MGI ID: |
MGI:3836050 |
| Transgene: |
Tg(Scgb1a1-rtTA,tetO-Il11)1Eli Location: unknown
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| Alliance: |
Tg(Scgb1a1-rtTA,tetO-Il11)1Eli page
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| Strain of Origin: |
CBA x C57BL/6
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| Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence, Transactivator) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Mutation details: The CC10-rtTA-hGH construct contains the CC10 promoter, the reverse tetracycline transactivator (rtTA), and human growth hormone (hGH) intronic and polyadenylation sequences. The second construct contains a polymeric tetracycline operator (tet-O), minimal CMV promoter, and a human IL11 cDNA. Both constructs were coinjected into fertilized oocytes, and dual positive founder animals were obtained. In the presence of doxycycline (dox), rtTA is able to bind in trans to the tet-O, and the VP-16 transactivator activates LIF gene transcription. In the absence of dox, rtTA binding occurs at very low levels, and only low level gene transcription is noted.
(J:145769)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:145769 Waxman AB, et al., Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. J Clin Invest. 1998 May 1;101(9):1970-82 |
| All: |
2 reference(s) |
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Analysis Tools
