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Gene Expression Data
Assay Details
Assay
Reference: J:143543 Vogel T, et al., Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse. Gene Expr Patterns. 2009 Feb;9(2):83-93
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3835655
Gene symbol: Mllt3
Gene name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Reporter: lacZ
Direct Detection
Results
Specimen Not shown E7.75: embryonic day 7.75; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS11: embryo Absent
Specimen 1A: embryonic day 8.0; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS12: somite Present 1A
TS12: embryo Present Regionally restricted 1A Expression is in the caudal part of the embryo.
TS12: future prosencephalon Absent 1A
Specimen 1B: embryonic day 8.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS13: somite Strong 1B
TS13: embryo Strong Regionally restricted 1B Expression is in the caudal part of the embryo.
TS13: future hindbrain Present 1B
TS13: future midbrain Present 1B
TS13: heart Present 1B
TS13: future prosencephalon Absent 1B
Specimen 1C: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: midbrain roof plate Strong 1C
TS19: midbrain-hindbrain junction Strong 1C
TS19: midbrain Strong Regionally restricted 1C Expression is in the pretectal area.
Specimen 1D: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: midbrain roof plate Strong 1D
TS19: midbrain-hindbrain junction Strong 1D
TS19: midbrain Present Regionally restricted 1D Expression is in the pretectal area.
Specimen 1E: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present Regionally restricted 1E Expression is in posterior dorsal root ganglia and is absent in anterior ganglia.
Specimen 1F: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: neural tube Present Regionally restricted 1F
TS19: dorsal root ganglion Present Regionally restricted 1F Expression is in posterior dorsal root ganglia and is absent in anterior ganglia.
Specimen 1G: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present Regionally restricted 1G Expression is in posterior dorsal root ganglia and is absent in anterior ganglia.
Specimen 1H: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: midbrain roof plate Strong 1H
TS19: midbrain-hindbrain junction Strong 1H
Specimen 1I: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: midbrain Present Regionally restricted 1I Expression is in the pretectal area.
TS19: midbrain-hindbrain junction Present 1I
Specimen 1J: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: brain Present Regionally restricted 1J Expression is in the choroid plexus.
Specimen 1K: embryonic day 11.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS19: midbrain-hindbrain junction Present 1K
Specimen 1L: embryonic day 13.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present Regionally restricted 1L
TS21: medulla oblongata part of 4th ventricle choroid plexus Present 1L
TS21: metencephalon part of 4th ventricle choroid plexus Strong 1L
TS21: midbrain roof plate Strong 1L
TS21: midbrain Strong Regionally restricted 1L Expression is in the midline roof and extends from the epiphysis, to the pretectum and over the entire dorsal midline of the midbrain.
TS21: pons Strong Regionally restricted 1L Expression is in pontine nuclei.
Specimen Not shown E12.5: embryonic day 12.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS20: diencephalon Weak
TS20: telencephalon Weak
Specimen 1M: embryonic day 13.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS21: midbrain Strong Regionally restricted 1M Expression is in the midline roof and extends from the epiphysis, to the pretectum and over the entire dorsal midline of the midbrain.
TS21: midbrain roof plate Strong Regionally restricted 1M Expression is in the midline roof and extends from the epiphysis, to the pretectum and over the entire dorsal midline of the midbrain.
Specimen 1N: embryonic day 13.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 1N
TS21: cerebral cortex ventricular layer Present 1N
TS21: cortical plate Present 1N
TS21: cerebral cortex Present Regionally restricted 1N Expression is in the septum.
TS21: telencephalon Present Regionally restricted 1N Expression is absent from the basal ganglia.
Specimen 1O: embryonic day 13.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS21: telencephalon Present Regionally restricted 1O Expression is absent from the basal ganglia.
TS21: telencephalon mantle layer Present 1O
Specimen 1P: embryonic day 13.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS21: midbrain Strong Regionally restricted 1P Expression is in the midline roof and extends from the epiphysis, to the pretectum and over the entire dorsal midline of the midbrain. There are a few scattered cells are found in lateral regions of the midbrain.
TS21: midbrain roof plate Strong Regionally restricted 1P Expression is in the midline roof and extends from the epiphysis, to the pretectum and over the entire dorsal midline of the midbrain. There are a few scattered cells are found in lateral regions of the midbrain.
TS21: medulla oblongata Present Single cells 1P
Specimen 2A: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS24: thalamus Strong Regionally restricted 2A Expression is in the dorsal thalamus.
TS24: cerebral cortex intermediate zone Strong 2A
TS24: cerebral cortex subventricular zone Strong 2A
TS24: cortical plate Strong 2A
TS24: cerebral cortex Strong Regionally restricted 2A Expression is in the septum.
TS24: forebrain Strong Regionally restricted 2A Expression is in cells of the lateral migratory stream.
Specimen 2B: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS24: thalamus Strong Regionally restricted 2B Expression is ubiquitous in the rostral thalamus while only scattered cells are positive in caudal regions.
TS24: epithalamus Strong Regionally restricted 2B Expression is in the medial habenular nuclei.
TS24: cerebral cortex intermediate zone Strong 2B
TS24: cerebral cortex subventricular zone Strong 2B
TS24: forebrain Present Regionally restricted 2B Expression extends into the hippocampus.
Specimen 2C: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS24: thalamus Strong Regionally restricted 2C Expression is ubiquitous in the rostral thalamus while only scattered cells are positive in caudal regions.
TS24: midbrain roof plate Strong 2C
TS24: pineal gland Strong Regionally restricted 2C Expression is in the stalk of the epiphysis.
Specimen 2G: postnatal day 0; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS27: thalamus Present Graded 2G There is a rostral to caudal declining gradient.
TS27: cerebral cortex Present 2G
Specimen 2H: postnatal day 0; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS27: thalamus Present Graded 2H There is a rostral to caudal declining gradient.
TS27: cerebral cortex Present 2H
TS27: lateral geniculate nucleus Present 2H
Specimen 2I: postnatal day 0; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS27: thalamus Present Graded 2I There is a rostral to caudal declining gradient.
TS27: cerebral cortex Present 2I
Specimen Not shown Adult: postnatal adult; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS28: brain Present
Specimen Not shown E13.5: embryonic day 13.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS21: cerebellum Present Regionally restricted Expression is in the cerebellar neuroepithelium and the external germinal layer.
TS21: midbrain-hindbrain junction Present
Specimen 3A: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS24: hindbrain Present Regionally restricted 3A Expression is at the isthmus of the midbrain/hindbrain.
TS24: midbrain Present Regionally restricted 3A Expression is at the isthmus of the midbrain/hindbrain.
TS24: cerebellum Present Regionally restricted 3A Expression is in the cerebellar neuroepithelium and the external germinal layer.
Specimen 3B: postnatal day 0; Mllt3tm1Thr/Mllt3+ (more )
Structure Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Present 3B
TS27: cerebellum external granule cell layer Present 3B
Specimen 4A Svet1: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Svet1 (assay MGI:3835945).
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 4A
Specimen 4B Svet1: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Svet1 (assay MGI:3835945).
Structure Level Pattern Image Note
TS24: cortical plate Present 4B
Specimen 4C Tbr2: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; brown - Eomes (Tbr2; assay MGI:3835952).
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 4C
TS24: cerebral cortex ventricular layer Absent 4C
Specimen 4D Tbr2: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; brown - Eomes (Tbr2; assay MGI:3835952).
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 4D
TS24: cerebral cortex ventricular layer Absent 4D
Specimen 4E BrdU: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; brown - BrdU.
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 4E
Specimen 4F PH3: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - phosphorylated histone.
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 4F
Specimen 4G L1: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - L1cam (assay MGI:3835957).
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 4G
Specimen 4H L1: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - L1cam (assay MGI:3835957).
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 4H
Specimen 4I Tbr1: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Tbr1 (assay MGI:3835959).
Structure Level Pattern Image Note
TS24: cortical subplate Present 4I Expression is in upper and deep layer neurons.
Specimen 4J Tbr1: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Tbr1 (assay MGI:3835959).
Structure Level Pattern Image Note
TS24: cortical subplate Present 4J
Specimen 5U: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Mllt3 RNA (assay MGI:3835855).
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 5U
Specimen 5V: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Cux2 (assay MGI:3835946).
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present 5V
Specimen 5W: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Mllt3 RNA (assay MGI:3835855).
Structure Level Pattern Image Note
TS24: cortical plate Present Regionally restricted 5W Expression is in upper level neurons.
Specimen 5X: embryonic day 16.5; Mllt3tm1Thr/Mllt3+ (more )
Note: Double labeled: blue - Mllt3 reporter; purple - Cux2 (assay MGI:3835946).
Structure Level Pattern Image Note
TS24: cortical plate Present Regionally restricted 5X Expression is in upper level neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory