Tg(Thy1-PRSS12)491Zbz
Transgene Detail
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| Symbol: |
Tg(Thy1-PRSS12)491Zbz |
| Name: |
transgene insertion 491, University of Zurich |
| MGI ID: |
MGI:3832224 |
| Synonyms: |
SARCO, Tg(PRSS12)491Zbz |
| Transgene: |
Tg(Thy1-PRSS12)491Zbz Location: unknown
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| Alliance: |
Tg(Thy1-PRSS12)491Zbz page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-PRSS12)491Zbz expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PRSS12 (8492) |
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Mutation details: A human neurotrypsin cDNA was subcloned into the XhoI site of the murine Thy1.2 genomic expression cassette. A loxP-flanked transcription termination cassette was inserted between the Thy1 promoter and the translational start codon of neurotrypsin. Mice carrying this transgene were mated with constitutively expressing Cre mice to delete the floxed transcription termination cassette and activate the dormant transgene.
(J:136579)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:136579 Stephan A, et al., Neurotrypsin cleaves agrin locally at the synapse. FASEB J. 2008 Jun;22(6):1861-73 |
| All: |
4 reference(s) |
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Analysis Tools
