Gene Expression Data
Assay Details
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Assay
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Reference:
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J:43748
Lee KF, et al., Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell. 1992 May 29;69(5):737-49
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:3830498
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Gene symbol:
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Calca
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Gene name:
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calcitonin/calcitonin-related polypeptide, alpha
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Antibody:
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ANTI-CGRP
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Detection system:
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Secondary antibody coupled to rhodamine
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Results
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Specimen
5A,B:
postnatal adult
(more  )
Note: Section through footpad.
Specimen
5A,B:
(close  )
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Genetic Background:
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involves: 129S4/SvJae * BALB/c
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Section through footpad.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: foot skin |
Present |
Regionally restricted |
5A/B
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| TS28: nerve |
Present |
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5A/B
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| TS28: dermis |
Present |
Regionally restricted |
5A/B
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Expression in fibers coursing through dermis individually and in small-diameter nerves, and also in axons ramifying directly underneath and in some cases penetrating into the epidermis
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| TS28: epidermis |
Present |
Regionally restricted |
5A/B
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Expression in fibers in small diameter nerves and in an extensive plexus beneath the epidermis, with individual fibers terminating in the basal layers of epidermis.
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Specimen
5C,D:
(close )
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Genetic Background:
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involves: 129S4/SvJae * BALB/c
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Mutant Allele(s):
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Ngfrtm1Jae/Ngfrtm1Jae
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Section through footpad.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: foot skin |
Trace |
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5C/D
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Authors report that expression was almost entirely absent.
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| TS28: dermis |
Trace |
Regionally restricted |
5C/D
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Expression in fewer fibers in the dermis, with no expression in small-diameter nerves, and in fewer single fibers in the subepidermal region.
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| TS28: epidermis |
Absent |
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5C/D
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Analysis Tools