Tg(KRT14-Gdnf)324Kma
Transgene Detail
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| Symbol: |
Tg(KRT14-Gdnf)324Kma |
| Name: |
transgene insertion 324, Katheryn M Albers |
| MGI ID: |
MGI:3829501 |
| Synonyms: |
GDNF-OE |
| Transgene: |
Tg(KRT14-Gdnf)324Kma Location: unknown
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| Alliance: |
Tg(KRT14-Gdnf)324Kma page
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| Strain of Origin: |
(C3H x C57BL/6)F1
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(KRT14-Gdnf)324Kma expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Gdnf (MGI:107430) |
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Mutation details: The K14-GDNF transgene contains 2.3 kb of the human K14 keratin promoter sequence, the mouse GDNF cDNA and intron-exon splice sites from the human growth hormone gene. ELISAs were done to measure peptide levels in the skin, DRG, spinal cord, and plasma of adult GDNF-OE and wild-type mice. A sixfold increase of GDNF protein was detected in transgenic skin, whereas in DRG a 4.23-fold increase was measured. Spinal cord levels were also increased by 2.67-fold, suggesting anterograde transport of GDNF from the DRG to the dorsal horn. GDNF was not detected in the plasma of either wild-type or transgenic animals.
(J:76684)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:76684 Zwick M, et al., Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. J Neurosci. 2002 May 15;22(10):4057-65 |
| All: |
4 reference(s) |
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Analysis Tools
