Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	AurkaGt(XQ0149)Wtsi
Name:	aurora kinase A; gene trap XQ0149, Wellcome Trust Sanger Institute
MGI ID:	MGI:3826513
Gene:	Aurka  Location: Chr2:172198110-172212455 bp, - strand  Genetic Position: Chr2, 94.84 cM
Alliance:	AurkaGt(XQ0149)Wtsi page

Mutant Cell Line:	XQ0149
Germline Transmission:	Earliest citation of germline transmission: J:143099
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT0lxf   Mutation details: The gene trap vector pGT0lxf was inserted at intron 6. Neither the predicted fusion protein nor a truncated protein were detected. (J:143099) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select XQ0149 CL459510 (MGI Seq Detail) 5' RACE Chr2:172204694-172206416 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 18 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying AurkaGt(XQ0149)Wtsi

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aurka Mutation:	40 strains or lines available

Original:	J:143099 Lu LY, et al., Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem. 2008 Nov 14;283(46):31785-90
All:	1 reference(s)